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Ongoing Alzheimer's drug trials under scrutiny despite regulatory concerns

Ongoing Alzheimer's drug trials under scrutiny despite regulatory concerns

A pharmaceutical company's attempt to win approval for a new Alzheimer's treatment, simufilam, continues amid a flurry of controversy and regulatory challenges. Recent investigations have cast doubt on the basic studies supporting simufilam. These concerns increased when scientific journals retracted several studies and key figures at Cassava Sciences, the drug's sponsor, resigned. Despite these setbacks, in September the Securities and Exchange Commission (SEC) accused Cassava Sciences of disseminating misleading data about their clinical trials. However, the company settled these charges by paying $40 million, without admitting any guilt. Interestingly, simufilam is still undergoing Phase 3 trials, involving more than 1,900…
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Biden officials act to prevent Medicare drug premium increases before election

Biden officials act to prevent Medicare drug premium increases before election

In an effort to mitigate potential backlash in the upcoming presidential election, the Biden administration announced a significant reduction in Medicare drug premiums for 2025, achieved by allocating billions in subsidies to insurers. This strategic decision aims to prevent increased costs for older Americans, who represent a crucial voter base. The administration used funds from the Medicare fund to subsidize insurance companies, preventing what could have been a sharp increase in premiums due to the $2,000 annual cap on out-of-pocket expenses introduced by President Biden's Inflation Reduction Act. Without this government intervention, older individuals could have faced an annual increase…
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At 60 and a widow, she rediscovers romance

At 60 and a widow, she rediscovers romance

“Life After Love” explores the poignant journey of finding companionship after a significant loss. This narrative reveals the transformative experience of dating as an elderly widow. Four months after losing her spouse after three decades of marriage, Kathryn Shephard Cowan ventured back into the dating scene with a visit to the symphony orchestra with a seemingly agreeable gentleman. Despite her initial determination, Kathryn found herself unexpectedly overwhelmed by the music of Beethoven, her late husband's favorite composer, leaving her unable to connect with her date. This story, written by Catherine Pearson, a journalist renowned for her insights into family and…
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Closing the antibiotic gap: access versus resistance in infection control

Closing the antibiotic gap: access versus resistance in infection control

The global fight against infectious diseases is undergoing a fundamental shift in perspective. For years, the dominant narrative around antimicrobial resistance (AMR) has focused on the overuse of antibiotics, painting a picture of a world grappling with increasingly ineffective drugs. While the dangers of overprescribing remain real, a growing chorus of experts argue that this focus overlooks a more fundamental issue: Millions of people don't have access to even the most basic antibiotics. At a recent United Nations meeting, health leaders highlighted this overlooked aspect of antimicrobial resistance. The inability of poor families to afford a simple course of antibiotics,…
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Dr. John A. Clements, Pioneer of Lifesaving Neonatal Treatment, Dies at 101

Dr. John A. Clements, Pioneer of Lifesaving Neonatal Treatment, Dies at 101

Dr. John A. Clements, a preeminent figure in pulmonary science who deciphered critical lung function in the 1950s and later developed a revolutionary drug to treat lung failure in newborns, has died at his home in Tiburon, California. He was 101. His disappearance was confirmed by his daughter, Carol Clements. Dr. Clements' pioneering work began shortly after his graduation from Cornell University Medical College (now Weill Cornell Medical College) while serving as an Army physiologist. He was fascinated by the mechanics of human respiration, particularly how the tiny air sacs in the lungs manage to stay open during exhalation. Determined…
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